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Cyclodextrins micrometric powders obtained by supercritical fluid processing
Author(s) -
Reverchon E.,
Antonacci A.
Publication year - 2006
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.20895
Subject(s) - micronization , supercritical fluid , chemical engineering , raw material , amorphous solid , precipitation , cyclodextrin , particle size , particle (ecology) , materials science , particle size distribution , chromatography , chemistry , organic chemistry , physics , oceanography , meteorology , engineering , geology
Supercritical fluid technology offers the possibility to produce dry powder formulations of biocompatible materials, overcoming the drawbacks of classical micronization processes. In this work, Supercritical Assisted Atomization (SAA) has been used to micronize α‐cyclodextrin (α‐CD) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD). Some process parameters, such as precipitation temperature and solute concentration in the liquid solution, have been studied to evaluate their influence on morphology and size of precipitated particles. Cyclodextrins (CDs) micronization has been successful: well‐defined spherical microparticles of α‐CD and HP‐β‐CD have been produced. Particle size analysis revealed that sharp distributions have been obtained: 95% of particles have diameters ranging between 0.1 and 5 µm for both CDs. X‐ray and DSC analyses have been also performed to investigate CDs modifications induced by SAA processing: amorphous particles have been obtained in both cases, whereas raw α‐CD was crystalline and raw HP‐β‐CD was amorphous. © 2006 Wiley Periodicals, Inc.