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Direct patterning of centrosome arrays as templates for the assembly of microtubules
Author(s) -
Shang Wen,
Dordick Jonathan S.,
Palazzo Robert E.,
Siegel Richard W.
Publication year - 2006
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.20846
Subject(s) - centrosome , microtubule , astral microtubules , template , microtubule nucleation , microbiology and biotechnology , organelle , nanotechnology , biology , chemistry , materials science , cell , genetics , cell cycle
We have achieved, for the first time, the selective patterning of centrosomes onto solid substrates. The use of such patterned centrosome arrays as templates for the directed polymerization of microtubules was also demonstrated. Centrosomes are small organelles in animal cells that serve as nucleation and organization centers of microtubules. Directed assembly of microtubules on the patterned centrosome arrays provides a new route to control the positions and directions of microtubules on surfaces. Combining the patterning of the isolated centrosomes and the directed growth of microtubules may lead to the generation of desired microtubule networks for bio‐based nanodevices. © 2006 Wiley Periodicals, Inc.