Investigation and characterization of liquid two‐phase systems for the separation of crystal mixtures by interfacial partitioning | Zendy

Hoeben Martijn A. | Zendy; van Hee Pim | Zendy; van der Lans Rob G.J.M. | Zendy; Kwant Gerard | Zendy; van der Wielen Luuk A.M. | Zendy

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Investigation and characterization of liquid two‐phase systems for the separation of crystal mixtures by interfacial partitioning

Author(s) -

Hoeben Martijn A.,

van Hee Pim,

van der Lans Rob G.J.M.,

Kwant Gerard,

van der Wielen Luuk A.M.

Publication year - 2006

Publication title -

biotechnology and bioengineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.136

H-Index - 189

eISSN - 1097-0290

pISSN - 0006-3592

DOI - 10.1002/bit.20653

Subject(s) - dodecane , pentane , chemistry , phase (matter) , butanol , adsorption , chromatography , methanol , partition (number theory) , partition coefficient , chemical physics , thermodynamics , chemical engineering , organic chemistry , ethanol , mathematics , combinatorics , engineering , physics

The interfacial partitioning behavior of ampicillin and phenylglycine crystals in different two‐phase systems has been investigated. The two‐phase systems employed are water/dodecane, water/1‐butanol, and water/pentane/methanol. By means of partition experiments and microscopic imaging, it has been shown that the mechanism of separation strongly depends on the choice of the two‐phase system. While water/dodecane features a mechanism of sheer competitive adsorption at the interface, separation in water/1‐butanol is mainly due to partitioning into both liquid phases, leading to a higher degree of separation. Experiments with water/pentane/methanol have illustrated the large potential of three‐component systems, as slight variations in the composition can have large effects on the separation. © 2006 Wiley Periodicals, Inc.

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