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Compression of biocompatible liquid‐filled HSA‐alginate capsules: Determination of the membrane mechanical properties
Author(s) -
Carin Muriel,
BarthèsBiesel Dominique,
EdwardsLévy Florence,
Postel Caroline,
Andrei Diana Cristina
Publication year - 2003
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.10559
Subject(s) - membrane , capsule , compression (physics) , materials science , biocompatible material , composite material , deformation (meteorology) , constitutive equation , modulus , shear (geology) , biomedical engineering , chemistry , thermodynamics , medicine , biochemistry , botany , physics , finite element method , biology
Compression experiments between two parallel plates are performed on a series of biocompatible HSA‐alginate capsules with two different membrane thicknesses. The capsule geometry and size as well as the average membrane thickness are first measured. The compression set‐up is fitted with a sensitive force transducer that allows measurement of the compression force as a function of plate separation. The response of the capsule is analyzed by assuming different constitutive models for the membrane, where the shear and surface dilatation effects are accounted. An apparent area dilatation modulus is then computed for different values of the plate separation and required to remain constant as the capsule deformation increases. This allows identification of plausible constitutive laws for the membrane material. © 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 82: 207–212, 2003.