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Modified model for the regulation of the tryptophan operon in Escherichia coli
Author(s) -
Giona Massimiliano,
Adrover Alessandra
Publication year - 2002
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.10373
Subject(s) - trp operon , tryptophan , operon , lac operon , escherichia coli , l arabinose operon , chemistry , gal operon , biology , biochemistry , amino acid , gene
This article proposes a modification of the model developed by Sinha (1988) and Sen and Liu (1990) for the regulation dynamics of the tryptophan operon in E. coli based on a consistent overall balance of the agent repressing the mRNA transcription. The dynamics of the model are analyzed by means of continuation techniques and the influence of periodic fluctuations in the intracellular demand for tryptophan is addressed. The analysis provides deeper insight into the dynamics of this operon system and the results obtained may be a useful starting point for the optimization of tryptophan yield in bacterial cultures. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 80: 297–304, 2002.

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