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Mathematical analysis of solid–liquid mass transfer in a batch reactor for the enzymatic transformation of testosterone to 4AD
Author(s) -
Patel Shwetal,
Mehra Anurag
Publication year - 2002
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.10327
Subject(s) - mass transfer , mixing (physics) , chemistry , transformation (genetics) , chromatography , mass transfer coefficient , convection , phase (matter) , thermodynamics , biochemistry , organic chemistry , physics , quantum mechanics , gene
Abstract A previous mathematical analysis of mass transfer in a two‐phase (solid–liquid) batch reactor for enzymatic transformation of testosterone to 4AD (Pereira et al., 1987) is extended to incorporate the effect of convective mixing. The results of the analysis showed that for a given enzyme loading, the mass transfer resistance in the solid (a function of the bead size) and the intensity of convective mixing (as embodied in the mass transfer coefficient) are two parameters that can be varied such that the overall mass transfer rate from the solid to the liquid phase ensures optimal reactor performance. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 79: 647–652, 2002.