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Polymer surfaces derivatized with poly(vinyl‐ N ‐hexylpyridinium) kill airborne and waterborne bacteria
Author(s) -
Tiller Joerg C.,
Lee Sang Beom,
Lewis Kim,
Klibanov Alexander M.
Publication year - 2002
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.10299
Subject(s) - polymer , coating , bacteria , covalent bond , bromide , pyridinium , aqueous solution , surface modification , chemical engineering , polyacrylamide , chemistry , materials science , organic chemistry , polymer chemistry , genetics , engineering , biology
A facile methodology has been developed for covalently derivatizing the surfaces of common materials with a designed antibacterial polycation, poly(vinyl‐ N ‐pyridinium bromide), wherein the first, key step involves surface coating with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner become bactericidal—they kill up to 99% of deposited, from either an aerosol or an aqueous suspension, Gram‐positive and Gram‐negative bacteria on contact. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 79: 465–471, 2002.