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Protein structural analysis as a tool for protein design
Author(s) -
Leplae Raphael,
Lahm Armin,
Tramontane Anna
Publication year - 1995
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360370604
Subject(s) - protein design , computational biology , chemistry , protein structure , sequence (biology) , protein engineering , computer science , biochemistry , biology , enzyme
The analysis of known protein structures is a very valuable and indispensable tool for deciphering the complex rules relating sequence to structure in proteins. On the other hand, the design of novel proteins is certainly the most severe test of our understanding of such rules. In this report we describe our own attempt to develop appropriate tools for the investigation of known protein structure properties and their applications to the design of a novel, all β protein. The success of the design project is a demonstration of the usefulness of careful analysis of the data base of known protein structures. © 1994 John Wiley & Sons, Inc.