Specific interaction between cyclophilin and cyclic peptides | Zendy

Gallo Pasquale | Zendy; Saviano Michele | Zendy; Rossi Filomena | Zendy; Pavone Vincenzo | Zendy; Pedone Carlo | Zendy; Ragone Raffaele | Zendy; Stiuso Paola | Zendy; Colonna Giovanni | Zendy

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Specific interaction between cyclophilin and cyclic peptides

Author(s) -

Gallo Pasquale,

Saviano Michele,

Rossi Filomena,

Pavone Vincenzo,

Pedone Carlo,

Ragone Raffaele,

Stiuso Paola,

Colonna Giovanni

Publication year - 1995

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.360360303

Subject(s) - cyclophilin , chemistry , cyclophilin a , cis trans isomerases , fkbp , isomerase , peptidylprolyl isomerase , stereochemistry , derivative (finance) , isomerization , prolyl isomerase , biophysics , biochemistry , pin1 , enzyme , microbiology and biotechnology , gene , financial economics , economics , biology , catalysis

Cyclophilin A, a peptidyl‐prolyl cis–trans isomerase that catalyzes the otherwise slow isomerization of Xaa‐Pro imidic bond, specifically binds the immunosuppressant cyclosporin A. Herein we reportevidence on binding of cyclolinopeptide A and its synthetic analogue, [Aib 5,6 ‐ D ‐Ala 8 ] cyclolinopeptide, to bovine cyclophilin A. Binding experiments were monitored by fluorescence. CD, and second‐derivative spectroscopies, evidencing no remarkable rearrangement of protein structure organization. The possibility that cyclolinopeptide A could act as a substitute of cyclosporin A in the immunosuppression modulation is also briefly discussed. © 1995 John Wiley & Sons, Inc.

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