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Solution structure and dynamics of a glycoinositol phospholipid (GIPL‐6) from Leishmania major
Author(s) -
Weller C. T.,
McConville M.,
Homans S. W.
Publication year - 1994
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360340905
Subject(s) - chemistry , moiety , glycosidic bond , phosphodiester bond , residue (chemistry) , glycan , stereochemistry , phospholipid , molecular dynamics , molecule , nuclear magnetic resonance spectroscopy , computational chemistry , membrane , biochemistry , organic chemistry , rna , glycoprotein , gene , enzyme
By use of a combination of 1 H nuclear Overhauser effect measurements, restrained molecular dynamics simulations, and 13 C spin–lattice relaxation time measurements, the solution behavior of the glycan moiety of a complex glycoinositol phospholipid termed G1PL‐6, from the protozoan parasite Leishmania major has been determined. The glycan moiety of GIPL‐6 has the following structure, which is characterized by the presence of an internal β‐galactofuranose residue:The glycan does not adopt a single conformation in solution, due to significant torsional variations about the two phosphodiester linkages and certain glycosidic linking in the molecule. The present of the internal galactofuranose residue results in an average solution conformation of the oligosaccharide, which resembles a “hairpin,” with the galactofuranose residue at the apex. © 1994 John Wiley & Sons, Inc.