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Comparative study of the interactions of cisplatin and carboplatin with nucleotides using UV resonance raman spectroscopy
Author(s) -
Benson Ronda L.,
Gustafson Terry L.
Publication year - 1993
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360331102
Subject(s) - chemistry , carboplatin , nucleotide , resonance raman spectroscopy , raman spectroscopy , cisplatin , resonance (particle physics) , platinum , molecule , free base , absorption spectroscopy , excited state , stereochemistry , biochemistry , organic chemistry , chemotherapy , medicine , physics , salt (chemistry) , surgery , optics , particle physics , quantum mechanics , nuclear physics , gene , catalysis
We have obtained the UV excited resonance Raman spectra of five mononucleotides bound to cisplatin and to carboplatin using excitation in resonance with the first electronic absorption bands of the nucleotide bases. Substantial changes in the spectra are observed following interaction with both platinum drugs, indicating modifications to nucleotide structure. Pt (II) binds to base portions of the nucleotide molecules, altering their normal modes of vibration significantly. We present comparative data of cisplatin and carboplatin, and discuss the implications of these results. The kinetics of the drug/nucleotide reactions differ, but final products are found to be similar. © 1993 John Wiley & Sons, Inc.