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The preparation and characterization of a twin‐tailed, lipid‐linked polysialic acid
Author(s) -
Matthews Ian,
Petrak Karel
Publication year - 1993
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360330311
Subject(s) - polysialic acid , chemistry , characterization (materials science) , biochemistry , sialic acid , nanotechnology , cell , cell adhesion , materials science , neural cell adhesion molecule
Reactions between water‐insoluble and water‐soluble components are often slow, giving low yields. In order to prepare glycolipids composed of polysialic acid and N‐(4‐(p‐maleimidylphenyl)butyryl)dipalmitoyl‐ L ‐α‐phosphatidylethanol amine triethylammonium salt, we used liposomes to enhance the interfacial reaction between the reagents. Thus, thiolreactive liposomes were reacted with polysialic acid cysteamine. A 70% yield was achieved with this addition reaction, and the product was isolated by dialysis and centrifugation © 1993 John Wiley & Sons, Inc.