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Peptide–membrane interactions and a new principle in quantitative structure–activity relationships
Author(s) -
Schwyzer Robert
Publication year - 1991
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360310624
Subject(s) - chemistry , peptide , membrane , perspective (graphical) , biophysics , selectivity , cell membrane , receptor , action (physics) , computational biology , biochemistry , physics , quantum mechanics , artificial intelligence , computer science , biology , catalysis
Ideas about “active conformations” of peptides as the basis of their biological action are reviewed and put into perspective with recent work on the possible role of the lipid phase of the target cell membrane in mediating receptor subtype selectivity.