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On the kinetics of oligomer binding
Author(s) -
Poland Douglas
Publication year - 1990
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360301307
Subject(s) - oligomer , kinetics , chemistry , polymer , thermodynamics , computational chemistry , polymer chemistry , organic chemistry , classical mechanics , physics
The kinetics of oligomer binding to a polymer are treated in the approximation that the internal states of the oligomer–polymer complex equilibrate rapidly compared with the rate of binding. In that case one can use equilibrium statistical mechanics to give the density of appropriate binding sites required in the kinetic equation. In this manner one can obtain a general differential equation in one variable (the net density of oligomer bound) for the case of cooperative binding. Several simple, but accurate, approximate solutions to the binding kinetics are presented.