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Melanin‐concentrating hormone: A structural and conformational study based on synthesis, biological activity, high‐field nmr, and molecular modeling techniques
Author(s) -
Brown D. W.,
Campbell M. M.,
Kinsman R. G.,
White P. D.,
Moss C. A.,
Osguthorpe D. J.,
Paul P. K. C.,
Baker B. I.
Publication year - 1990
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360290314
Subject(s) - chemistry , melanin concentrating hormone , molecular model , molecular dynamics , peptide , melanin , stereochemistry , computational chemistry , biochemistry , neuropeptide , receptor
A series of Melanin‐concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5‐14 linear and 5‐14 cyclic, have been used as models for MCH—in 1 H‐nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.