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Interactions of nucleic acids with distamycins. The drug monomeric chromophore
Author(s) -
Forni A.,
Moretti I.,
Torre G.,
Marconi G.,
Samori B.
Publication year - 1989
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360281209
Subject(s) - chemistry , chromophore , thermotropic crystal , monomer , circular dichroism , linear dichroism , spectral line , netropsin , crystallography , spectroscopy , stereochemistry , photochemistry , organic chemistry , molecule , phase (matter) , liquid crystalline , physics , minor groove , astronomy , quantum mechanics , polymer
A study of the monomeric chromophore of the oligopeptides netropsin (1), distamycin III (2), and distamycin V (3) by polarization spectroscopy techniques 1 and molecular orbital calculations is reported. Linear dichroism spectra of the monomeric model compounds 1‐methyl‐2(ethylcarbamoyl)‐4‐acetamido‐pyrrole (4) and 1‐methyl‐2(ethylcarbamoyl)‐pyrrole (5) dissolved and oriented in lyotropic and thermotropic liquid crystals provide, together with the magnetic CD spectra, experimental checks of the theoretical calculations. The polarization directions of the investigated transition obtained by these means in this study allow us to build up in the following paper 2 the exciton states of (1)‐(3) and these provide a stereochemical interpretation of the flow linear dichroism spectra of the complexes of DNA with (2) and (3).