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Aggregation of amphotericin B in the presence of γ‐cyclodextin
Author(s) -
Kajtár M.,
Vikmon M.,
Morlin E.,
Szejtli J.
Publication year - 1989
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360280908
Subject(s) - chemistry , amphotericin b , aqueous solution , cyclodextrin , amorphous solid , colloid , precipitation , absorption (acoustics) , drug , nuclear chemistry , chromatography , stereochemistry , organic chemistry , pharmacology , microbiology and biotechnology , antifungal , medicine , physics , meteorology , acoustics , biology
The macrolide antibiotic amphotericin B (AmB) forms an inclusion complex with γ‐cyclodextrin (γ‐CDx), resulting in a molecularly dispersed state of the drug. The state of aggregation of AmB in different solvents has been studied by absorption (uv‐vis) and CD spectroscopy. While in aqueous solutions AmB forms colloid‐like multimolecular aggregates, in the presence of γ‐CDx true solutions can be prepared, which show similar spectral properties as AmB dissolved in organic solvents. The AmB–γ‐CDx complex can be isolated as an amorphous, stable, water‐soluble powder, indicatin that γ‐CDx is a good carrier for the solubilization of this antibiotic. Using γ‐CDx as a carrier, the danger of precipitation of the drug during parenteral or intravenous administration can be largely reduced.