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Ala analogues of the cyclolinopeptide A
Author(s) -
Zanotti Giancarlo,
Tancredi Teodorico,
Rossi Filomena,
Benedetti Ettore,
Pedone Carlo,
Temussi Pierandrea
Publication year - 1989
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360280135
Subject(s) - chemistry , stereochemistry
Abstract Analogues of cyclolinopeptide A, due to the replacement of each amino acid in the Pro 1 ‐Pro 2 ‐Phe 3 ‐Phe 4 sequences with an L ‐Ala residue, were synthesized by classical method in solution. Mixed anhydride and N,N′‐dicyclohexylcarbodiimide coupling methods have been used for the synthesis of both linear and cyclic peptides. The products were characterized by R f values and uv spectra, as well as by fast atom bombardment spectroscopy. 1 H‐nmr studies on [Ala 2 ] analogues are also reported. Preliminary data in CDCI 3 solution, at low temperature, seems more promising.