Bicyclic peptides: Solution conformation and Ca 2+  binding of the heterodetic bicyclic decapeptide cyclo(Glu 1 ‐Leu 2 ‐Pro 3 ‐Gly 4 ‐Ser 5 ‐Ile 6 ‐Pro 7 ‐Ala 8 )‐cyclo(1γ → 5β) Phe 9 ‐Gly 10 | Zendy

Zanotti Giancarlo | Zendy; Pinnen Francesco | Zendy; Lucente Gino | Zendy; Paolillo Livio | Zendy; D'Auria Gabriella | Zendy; Trivellone Enrico | Zendy; D'Alagni Maria | Zendy

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Bicyclic peptides: Solution conformation and Ca 2+ binding of the heterodetic bicyclic decapeptide cyclo(Glu 1 ‐Leu 2 ‐Pro 3 ‐Gly 4 ‐Ser 5 ‐Ile 6 ‐Pro 7 ‐Ala 8 )‐cyclo(1γ → 5β) Phe 9 ‐Gly 10

Author(s) -

Zanotti Giancarlo,

Pinnen Francesco,

Lucente Gino,

Paolillo Livio,

D'Auria Gabriella,

Trivellone Enrico,

D'Alagni Maria

Publication year - 1989

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.360280131

Subject(s) - bicyclic molecule , chemistry , intramolecular force , stereochemistry , nuclear magnetic resonance spectroscopy , crystallography

The conformational behavior of a heterodetic bicyclic decapeptide (BCPLT) in the absence and in the presence of calcium ions has been studied by means of mono and two‐dimensional nmr techniques. Free BCPLT possesses a quite compact structure stabilized by intramolecular bonds and turns. In the structure a cluster of carbonyls is located in a cavity that is supposed to be the cation binding site.

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