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Structure and stability of the Boc( D ‐Pro‐ L ‐Pro) 2 OCH 3 Na + complex: A model of poly( D , L ‐proline), an alkali ion channel across membranes
Author(s) -
De Santis P.,
Scipioni A.,
Palleschi A.,
Savino M.
Publication year - 1989
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360280129
Subject(s) - chemistry , tetramer , monomer , membrane , alkali metal , nuclear magnetic resonance spectroscopy , ion , stereochemistry , crystallography , polymer , organic chemistry , biochemistry , enzyme
In order to elucidate the molecular mechanisms of alkali ions conduction of poly( D , L ‐proline), which shows the typical behavior of an ion channel across membranes, conformations of the tetrameric derivative Boc( D ‐Pro‐ L ‐Pro) 2 OCH 3 in solution, in the presence of the Na + ion, were investigated by CD and nmr spectroscopy. Both theoretical and experimental data indicate the formation in solution of a monomeric complex between the tetramer, in the all‐ trans conformation, and the cation. The results allow to confirm the channel model, previously proposed on the phenomenological behavior of poly( D , L ‐proline) in membranes.