Structure and stability of the Boc( D ‐Pro‐ L ‐Pro) 2 OCH 3  Na +  complex: A model of poly( D , L ‐proline), an alkali ion channel across membranes | Zendy

De Santis P. | Zendy; Scipioni A. | Zendy; Palleschi A. | Zendy; Savino M. | Zendy

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Structure and stability of the Boc( D ‐Pro‐ L ‐Pro) 2 OCH 3 Na + complex: A model of poly( D , L ‐proline), an alkali ion channel across membranes

Author(s) -

De Santis P.,

Scipioni A.,

Palleschi A.,

Savino M.

Publication year - 1989

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.360280129

Subject(s) - chemistry , tetramer , monomer , membrane , alkali metal , nuclear magnetic resonance spectroscopy , ion , stereochemistry , crystallography , polymer , organic chemistry , biochemistry , enzyme

In order to elucidate the molecular mechanisms of alkali ions conduction of poly( D , L ‐proline), which shows the typical behavior of an ion channel across membranes, conformations of the tetrameric derivative Boc( D ‐Pro‐ L ‐Pro) 2 OCH 3 in solution, in the presence of the Na + ion, were investigated by CD and nmr spectroscopy. Both theoretical and experimental data indicate the formation in solution of a monomeric complex between the tetramer, in the all‐ trans conformation, and the cation. The results allow to confirm the channel model, previously proposed on the phenomenological behavior of poly( D , L ‐proline) in membranes.

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