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Study of the bisintercalation of the antitumor drug ditercalinium by 31 P‐nmr
Author(s) -
Delepierre Muriel,
Igolen Jean,
Roques B. P.
Publication year - 1988
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360270606
Subject(s) - chemistry , intercalation (chemistry) , chemical shift , stereochemistry , nuclear magnetic resonance spectroscopy , carbazole , dimer , crystallography , organic chemistry
Bisintercalation of ditercalinium, a potent antitumoral 7H‐pyriodo[4,3‐c]carbazole rigid dimer, into the self‐complementary tetranucleotides d(CpGpCpG) 2 , d(m 5 CpGpm 5 CpG) and the self‐complementary hexanucleotide d(CpGpApTpCpG) 2 was investigated by 162‐MHz 31 P‐nmr. The slow exchange, on the nmr time scale, observed between the free and complexed nucleotides allows identification of the phosphorus signals in the complexes through two‐dimensional chemical exchange spectroscopy. Differences in 31 P chemical shifts upon intercalation are discussed in relation to the complex geometry and nature of the drug.