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Synthesis, and conformational and biological study of 2‐ D ‐Ala,5‐des‐Met‐enkephalin hydrazide modified at the carboxylic end by poly‐ N ‐vinylimidazole
Author(s) -
Vlasov G.,
Krasnikova E.,
Kozhevnikova N.,
Illarionova N.,
Denisov I.
Publication year - 1987
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360260904
Subject(s) - hydrazide , chemistry , tetrapeptide , carboxylic acid , enkephalin , stereochemistry , biological activity , in vivo , in vitro , biochemistry , organic chemistry , peptide , receptor , microbiology and biotechnology , opioid , biology
N , N ‐bis‐2‐ D ‐Ala,5‐des‐Met‐enkephalin hydrazide of azo‐isobutyric acid was synthesized. This was used to obtain polyvinylimidazole derivatives of an enkephalin analog, modified at the carboxylic end by poly‐ N ‐vinylimidazole. The effect of modification of tetrapeptide hydrazide on its conformational properties and biological activity in vivo and in vitro was studied.