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Conformation of the oligonucleotide d(AAAAAATTTTTT) 2 by two‐dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT)
Author(s) -
Roy Siddhartha,
Borah Babul,
Zon Gerald,
Cohen Jack S.
Publication year - 1987
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360260406
Subject(s) - nuclear overhauser effect , oligomer , chemistry , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , oligonucleotide , spectroscopy , proton , crystallography , stereochemistry , polymer chemistry , dna , biochemistry , physics , quantum mechanics
Conformational analysis from the pattern and intensities of cross‐peaks in the two‐dimensional nuclear Overhauser effect proton nmr spectra of the homopolymer, poly(dA) · poly(dT), and the analogous oligomer, d() 2 , indicate that they both exist in the B‐conformation. The conformation of the ApT/TpA junction in the oligomer is significantly different from the rest of the base pairs.