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Nucleic acid–metal interactions: V. The effect of silver(I) on the structures of A‐ and B‐DNA forms
Author(s) -
Nordén Bengt,
Matsuoka Yukio,
Kurucsev Tomas
Publication year - 1986
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360250811
Subject(s) - chemistry , dna , nucleic acid , aqueous solution , dichroic glass , metal , crystallography , spectral line , stereochemistry , inorganic chemistry , organic chemistry , nanotechnology , biochemistry , materials science , physics , astronomy
The interaction of silver(I) with DNA has been studied with uv LD in aqueous solution and in a humid anisotropic poly(vinyl alcohol) host (B‐DNA) and also in 80% ethanolic solution (A‐DNA). Addition of silver ions has a pronounced effect on the dichroic spectra of DNA, indicating that the DNA structure is significantly altered. By correlation with calculated reduced LD spectra, using intensities and moments of the corresponding electronic transitions of the DNA bases, the experimental spectra of DNA at high silver content may be interpreted in terms of tilt and roll angles of the bases in the double helix. In ethanolic A‐DNA solution there is a pronounced decrease in the orientation by flow of DNA, suggesting that the complexation of DNA to silver may be accompanied by the formation of compact tertiary structures.