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Spermine–nucleic acid interactions: A theoretical study
Author(s) -
Zakrzewska Krystyna,
Pullman Bernard
Publication year - 1986
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360250302
Subject(s) - nucleic acid , dodecameric protein , chemistry , spermine , dna , nucleic acid structure , rna , base pair , biochemistry , stereochemistry , enzyme , gene
The interaction of spermine with nucleic acids is simulated theoretically using refined semi‐empirical energy formulae and an advanced minimization procedure. Various nucleic acids are considered: model homopolymeric DNA's, a dodecamer (CGCGAATTCGCG) of type B‐DNA, as well as a transfer RNA, tRNA Phe . The dominant role of electrostatic potential in determining the preferential binding sites of spermine is demonstrated in each of these cases and the role of counterions, nucleic acid structure, and base‐pair sequence is analyzed.