Premium
Conformations of dinucleoside monophosphates in relation to duplex DNA structures
Author(s) -
Rao Shashidhar N.,
Sasisekharan V.
Publication year - 1986
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360250104
Subject(s) - polynucleotide , chemistry , nucleic acid , duplex (building) , stereochemistry , furanose , dna , stacking , conformational isomerism , crystallography , base pair , alkane stereochemistry , nucleotide , ring (chemistry) , biochemistry , molecule , crystal structure , organic chemistry , gene
Mononucleotide conformations are important in understanding the structural aspects of nucleic acids and polynucleotides. In order to study the influence of stacking interactions between adjacent bases in a polynucleotide on the preferred conformations of mononucleotides, conformational energy calculations have been carried out on dinucleoside monophosphate fragments. Four base sequences—d(ApT), d(TpA), d(CpG), and d(GpC)— have been analyzed in the framework of helical structures. Flexibility of the furanose ring has been incorporated in the investigations. Energetically favored conformers of the four compounds correspond to a variety of left‐ and right‐handed uniform helical structures, similar to those of the commonly observed polymorphous forms. Implications of these investigations on the further understanding of double‐helical polynucleotide conformations are briefly discussed.