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The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice
Author(s) -
Fujii Satoshi,
Wang Andrew H.J.,
Quigley Gary J.,
Westerink Henk,
Van Der Marel Gijs,
Van Boom Jacques H.,
Rich Alexander
Publication year - 1985
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360240118
Subject(s) - chemistry , crystallography , hexagonal crystal system , hexagonal lattice , lattice (music) , crystal structure , molecule , diffraction , dna , x ray crystallography , symmetry (geometry) , condensed matter physics , physics , optics , geometry , mathematics , biochemistry , organic chemistry , antiferromagnetism , acoustics
Both (dC‐dG) 4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c ‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.