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Cyclic peptides revisited
Author(s) -
Madison Vincent
Publication year - 1985
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360240109
Subject(s) - dihedral angle , chemistry , position (finance) , sequence (biology) , energy (signal processing) , algebraic number , cyclic peptide , energy minimization , crystallography , computational chemistry , peptide , physics , molecule , mathematics , quantum mechanics , mathematical analysis , hydrogen bond , biochemistry , organic chemistry , finance , economics
A multistep computational scheme was used to deduce possible conformations for a cyclic antagonist analog of somatostatin that has been reported by Coy and coworkers. An algebraic algorithm was used to find dihedral angles that give cyclic structures, the energy was computed for these structures, the lower‐energy structures were classified into conformational families, the energy was minimized for the lowest‐energy member of each family, and finally, the structures from energy minimization were reclassified. Analysis revealed seven distinct conformational families that contain reverse turns. The families differ in the position of the turns in the primary sequence; frame‐shifted turns are observed at each possible position.