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Conformation of cyclic analogs of enkephalin. II. Analogs containing a cystine bridge
Author(s) -
Hall David,
Pavitt Nicola
Publication year - 1984
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360231114
Subject(s) - chemistry , enkephalin , stereochemistry , molecular mechanics , cystine , ring (chemistry) , molecule , cysteine , biochemistry , enzyme , organic chemistry , receptor , opioid
A systematic survey has been made, using molecular mechanics, of the conformation of the ring entity of the enkephalin analogs, [ D ‐Cys 2 ‐ L ‐Cys 5 ]‐enkephalinamide and [ D ‐Cys 2 ‐ D ‐Cys 5 ]enkephalinamide. These molecules are considerably more flexible than the analog Tyr‐ cyclo ( N γ ‐ D ‐A 2 bu‐Gly‐Phe‐Leu‐), but the favored conformations of all three are very similar. The results of these studies are compatible with a Gly 3 ‐Phe 4 type II′ bend in the active conformation of enkephalin.