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Synthesis of oligopeptides consisting of L ‐leucyl‐ L ‐leucyl‐ L ‐ananyl and L ‐methionyl‐ L ‐methionyl‐ L ‐leucyl repeating units with an improved preparation of Nps‐amino acids
Author(s) -
Katakai Ryoichi,
Shida Hitoshi,
Takada Toshiaki
Publication year - 1984
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360230721
Subject(s) - chemistry , tripeptide , oligopeptide , stereochemistry , peptide , biochemistry
Two series of peptides with hydrophobic side chains, Nps‐( L ‐Leu‐ L ‐Leu‐ L ‐Ala) n ‐OEt and Nps‐( L ‐Met‐ L ‐Met‐ L Leu) n ‐OEt ( n = 1–6), were synthesized by the fragment condensation method using dicyclohexylcarbodiimide in the presence of N‐hydroxysuccinimide. The tripeptide fragments were prepared stepwise by dicyclohexylcarbodiimide‐mediated reaction of Nps‐amino acids, which were synthesized by an improved rapid procedure.