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X‐Ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG
Author(s) -
Aggarwal A.,
Islam S. A.,
Kuroda R.,
Neidle S.
Publication year - 1984
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360230605
Subject(s) - chemistry , crystallography , intercalation (chemistry) , proflavine , molecule , stereochemistry , base pair , ternary operation , dna , biochemistry , inorganic chemistry , organic chemistry , computer science , programming language
We report the crystal‐structure analysis of a complex involving the drug proflavine and the two dinucleoside monophosphates cytidylyl‐3′,5′‐adenosine (CpA) and uridylyl‐3′,5′‐guanosine (UpG). The planar drug molecule is intercalated between C ⃛G and U ⃛A Watson‐Crick base pairs, in a double‐helical fragmentlike arrangement. Sugar conformations at the 3′‐ends of the two strands are dissimilar. The backbone conformations fall within the ranges of values noted previously for dinucleoside intercalation complexes, and some correlations involving these are noted. The separation of the two strands and the basic twist angle of 16°, compared to other reported complexes, are indicative of sequence‐dependent effects of the drug binding.