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Proton NMR studies of partially modified retro–inverso peptides
Author(s) -
Ribeiro Anthony,
Chorev Michael,
Goodman Murray
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220805
Subject(s) - chemistry , amino acid residue , amino acid , stereochemistry , peptide , proton nmr , resolution (logic) , peptide sequence , combinatorial chemistry , biochemistry , artificial intelligence , computer science , gene
High‐resolution 1 H‐nmr analyses are presented for partially modified retro‐inverso derivatives of peptides with emphasis on enkephalins. Studies in DMSO‐d 6 reveal the unique as well as common characteristics of the non‐amino acid residues incorporated into these modified peptides. The complete assignment of 1,1‐diaminoalkyl and malonyl, as well as of amino acid, residues provides the basis for the exploration of the conformational features induced in peptides by such topochemical modifications.