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Copolymerization kinetics of N ‐carboxyanhydrides of some α‐amino acids: Influence of nature of amino acids
Author(s) -
Atreyi M.,
Rao M. V. R.,
Kumar Satish
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220213
Subject(s) - chemistry , comonomer , reactivity (psychology) , valine , glycine , kinetics , copolymer , amino acid , alanine , residue (chemistry) , tyrosine , norvaline , stereochemistry , polymer chemistry , organic chemistry , biochemistry , polymer , physics , alternative medicine , pathology , quantum mechanics , medicine
Studies on copolymerization kinetics of N ‐carboxyanhydride (NCA) of O ‐acetyl‐ L ‐tyrosine (T) with NCAs of L ‐valine (V) and glycine (G) were carried out in dioxane at 25°C with n ‐butylamine as initiator. The reactivity ratios for the VT system were found to be r V : r T :0.57:0.22; and for the GT system, r G : r T :0.26:0.42. A comparison of this data with that obtained when L ‐analine was used in place of L ‐valine or glycine showed that in the three systems, the reactivity ratio of the amino acid residue with a greater tendency to form ordered secondary structure was greater than that of its comonomer. Among the variable comonomers (glycine, L ‐alanine, L ‐valine) of O ‐acetyl‐ L ‐tyrosine, it is again L ‐alanine, whose tendency to form helical structure is very high, that has the greater reactivity ratio.