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Specific and nonspecific macromolecule–drug conjugates for the improvement of cancer chemotherapy
Author(s) -
Hurwitz Ester
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220168
Subject(s) - conjugate , chemistry , drug , antibody , methotrexate , chemotherapy , in vitro , pharmacology , conjugated system , doxorubicin , cancer research , biochemistry , immunology , medicine , mathematical analysis , mathematics , organic chemistry , polymer
Antineoplastic drugs such as daunomycin, adriamycin, methotrexate, 5‐fluorouridine, cytosine arabinoside, and platinate were bound to antibodies directly or via a polymeric bridge. The drug antibody conjugates retained most of their drug and antibody activities when tested in vitro . Daunomycin–antibody conjugates were shown to penetrate tumor cells in the conjugated form. In animals, daunomycin–antibody conjugates were at least as effective chemotherapeutically as the corresponding free drugs and considerably less toxic. In some tumor systems, the daunomycin–antibody conjugates represented an improvement over the free drug. This improvement was restricted in some tumors to a particular injection route of the tumor and the treatment.