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The key role of residue 5 in angiotensin II
Author(s) -
Fermandjian Serge,
Sakarellos Constantin,
Piriou Françlois,
Juy Michel,
Toma Flavio,
Thanh Hung Lam,
Lintner Karl,
Khosla Mahesh C.,
Smeby Robert R.,
Bumpus F. Merlin
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220131
Subject(s) - chemistry , residue (chemistry) , angiotensin ii , stereochemistry , renin–angiotensin system , biological activity , combinatorial chemistry , biochemistry , receptor , medicine , in vitro , blood pressure
The conformation–biological activity relationships in a series of angiotensin II analogs substituted in position 5 were studied. Results indicated that only analogs with β‐branched residue in position 5 possess spectral and biological properties identical to that of parent angiotensin II.
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