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Preferred conformations of peptides containing α,α‐disubstituted α‐amino acids
Author(s) -
Toniolo Claudio,
Bonora Gian Maria,
Bavoso Alfonso,
Benedetti Ettore,
di Blasio Benedetto,
Pavone Vincenzo,
Pedone Carlo
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220129
Subject(s) - chemistry , amino acid , peptide , stereochemistry , combinatorial chemistry , biochemistry
The conformational preferences of linear peptides containing α,α‐disubstituted α‐amino acids, derived from the crystal structures of 28 compounds, are reviewed. In particular, the sensitivity of peptide conformation to the geometry of these unusual amino acids is underlined. We also consider possible future directions of research, which, we hope, will result in a complete understanding of the structures adopted by peptaibol antibiotics.