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Conformational and functional properties of hemoglobin in water–organic cosolvent mixtures: Effect of ethylene glycol and glycerol on oxygen affinity
Author(s) -
Bulone Donatella,
Cupane Antonio,
Cordone Lorenzo
Publication year - 1983
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360220119
Subject(s) - chemistry , ethylene glycol , glycerol , hemoglobin , oxygen , ethylene , chemical engineering , organic chemistry , catalysis , engineering
We report on the effects that the presence of ethylene glycol or glycerol has on the oxygen affinity of hemoglobin. We attribute these effects to an altered equilibrium between T and R quaternary conformations of hemoglobin and separate them into bulk‐electrostatic and non‐bulk‐electrostatic contributions to the standard free‐energy difference between the R and T states.