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Microdomain dynamics in folding proteins
Author(s) -
Weaver D. L.
Publication year - 1982
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360210703
Subject(s) - folding (dsp implementation) , chemistry , protein folding , diffusion , dynamics (music) , collision , statistical physics , physics , thermodynamics , computer science , biochemistry , engineering , computer security , acoustics , electrical engineering
The basic formulas for the incorporation into the diffusion–collision model of the stabilities of intermediate states on the folding pathway are derived and discussed. A hypothetical two‐step folding pathway is calculated in detail. A model for the production of incorrectly folded intermediates is suggested and some numerical estimates made. Implications and future directions in the evolution of the model are discussed. Three appendices deal with some mathematical aspects of the model.