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Correlation between sugar pucker and the orientation around the C3′O3′ bond (Φ′) in 3′‐mononucleotides
Author(s) -
Dhingra M. M.,
Saran Anil
Publication year - 1982
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360210411
Subject(s) - chemistry , sugar , dihedral angle , nucleic acid , polynucleotide , torsion (gastropod) , crystallography , stereochemistry , hydrogen bond , molecule , organic chemistry , biochemistry , anatomy , medicine
Classical potential functions (CPF) calculations on 3′‐mononucleotides, the building blocks of nucleic acids, predict a correlation between the sugar ring pucker and the torsion angle Φ′ around the C3′O3′ bond. In ribonucleotides, the value of Φ′ depends on the sugar pucker, viz. the C2′‐ endo sugar pucker is associated with Φ′ = 210° and 270°, while the C3′‐ endo sugar pucker favors only Φ′ = 210°. On the other hand, in deoxyribonucleotides, both sugar puckers show a preference for Φ′ = 180°. These theoretical predictions are fully corroborated by the results obtained from x‐ray and nmr studies on mono‐, di‐, and polynucleotides.