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Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria
Author(s) -
Crothers Donald M.
Publication year - 1971
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360101110
Subject(s) - chemistry , nucleic acid , oligomer , oligonucleotide , polymer , thermodynamics , melting temperature , molecule , computational chemistry , dna , polymer chemistry , organic chemistry , biochemistry , physics , materials science , composite material
Equations are developed to describe the shift in the temperature of the helix–coil transition when small molecules bind to nucleic acids. Included are high polymers, oligonucleotides, and oligomer–polymer interactions. The equations prescribe simple ways of plotting experimental data to evaluate transition and binding parameters.