Premium
Rotatory properties of molecules containing two peptide groups: experimental and theoretical results
Author(s) -
Nielsen Eigil B.,
Schellman John A.
Publication year - 1971
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360100911
Subject(s) - chemistry , molecule , optical rotation , peptide , rigidity (electromagnetism) , computational chemistry , structural rigidity , solvent , interpretation (philosophy) , stereochemistry , crystallography , organic chemistry , physics , quantum mechanics , biochemistry , geometry , mathematics , computer science , programming language
Optical rotation studies were performed on five compounds containing two peptide groups. Four of the molecules were confined to restricted regions of conformational space by the presence of closed rings. Solvent and temperature were varied, and theoretical calculations were done for each compound covering the appropriate conformational space. The interpretation which results is qualitatively successful over the conformational regions covered by the compounds. Quantitative correlation between theory and experiment will require compounds of high rigidity.