A proton magnetic resonance study of the interaction of adenylyl (3′ → 5′) adenosine with polyuridylic acid | Zendy

Kreishman George P. | Zendy; Chan Sunney I. | Zendy

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A proton magnetic resonance study of the interaction of adenylyl (3′ → 5′) adenosine with polyuridylic acid

Author(s) -

Kreishman George P.,

Chan Sunney I.

Publication year - 1971

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.360100112

Subject(s) - chemistry , uracil , adenosine , stacking , resonance (particle physics) , proton magnetic resonance , nuclear magnetic resonance spectroscopy , base (topology) , proton , stereochemistry , crystallography , nuclear magnetic resonance , dna , biochemistry , organic chemistry , mathematical analysis , physics , mathematics , particle physics , quantum mechanics

The interaction of adenylyl (3′ → 5′) adenosine (ApA) with polyuridylic acid in D 2 O solution at neutral pD has been studied by high resolution proton magnetic, resonance spectroscopy. At temperatures above ∼32°C, no evidence was obtained for the interaction of ApA with poly U. Below this temperature, a rigid triple‐stranded complex involving a stoichiometry of 1 adenine to 2 uracil bases is formed, presumably via specific adenine–uracil base‐pairing and cooperative base stacking of the adenine bases in a manner similar to that previously reported for the adenosine–poly U complex.

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