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Interaction of polyadenylic acid with methylated xanthines
Author(s) -
Davies R. J. H.,
Davidson N.
Publication year - 1971
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360100104
Subject(s) - chemistry , theobromine , theophylline , hydrogen bond , dissociation (chemistry) , chloroform , stereochemistry , polymer chemistry , medicinal chemistry , organic chemistry , biochemistry , molecule , medicine , endocrinology
Polyadenylic acid forms both 1 : 1 and 2 : 1 complexes with 3‐methylxanthine under appropriate conditions. While the binding isotherms for formation of these complexes are typical of strongly cooperative processes, their melting profiles are anomalous and indicate that intermediate species are present during the thermal dissociation process. Theobromine and theophylline do not form complexes with polyadenylic acid under similar conditions, and they do not hydrogen‐bond very strongly with 9‐ethyludenine in chloroform solution.