Synthesis of poly‐ L ‐lysine and poly‐ L ‐lysyl albumin via ϵ, N ‐trifluoroacetyl‐α, N ‐carboxy‐ L ‐lysine anhydride | Zendy

Sela Michael | Zendy; Ar Ruth | Zendy; Jacobson Israel | Zendy

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Synthesis of poly‐ L ‐lysine and poly‐ L ‐lysyl albumin via ϵ, N ‐trifluoroacetyl‐α, N ‐carboxy‐ L ‐lysine anhydride

Author(s) -

Sela Michael,

Ar Ruth,

Jacobson Israel

Publication year - 1963

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.360010603

Subject(s) - lysine , chemistry , racemization , acetylation , methanol , piperidine , polymer chemistry , stereochemistry , biochemistry , organic chemistry , amino acid , gene

Free poly‐ L ‐lysine base has been synthesized from ϵ, N ‐trifluoroacetyl‐α, N ‐carboxy‐ L ‐lysine anhydride via poly‐ϵ, N ‐trifluoroacetyl‐ L ‐lysine (IV). No racemization occurred during the removal of trifluoroacetyl groups from IV with 1 M piperidine. Measurements of optical rotatory dispersion suggest that IV exists in methanol in a helical form. The synthesis of poly‐ L ‐lysyl rabbit serum albumin is also described.

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