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Synthesis of poly‐ L ‐lysine and poly‐ L ‐lysyl albumin via ϵ, N ‐trifluoroacetyl‐α, N ‐carboxy‐ L ‐lysine anhydride
Author(s) -
Sela Michael,
Ar Ruth,
Jacobson Israel
Publication year - 1963
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360010603
Subject(s) - lysine , chemistry , racemization , acetylation , methanol , piperidine , polymer chemistry , stereochemistry , biochemistry , organic chemistry , amino acid , gene
Free poly‐ L ‐lysine base has been synthesized from ϵ, N ‐trifluoroacetyl‐α, N ‐carboxy‐ L ‐lysine anhydride via poly‐ϵ, N ‐trifluoroacetyl‐ L ‐lysine (IV). No racemization occurred during the removal of trifluoroacetyl groups from IV with 1 M piperidine. Measurements of optical rotatory dispersion suggest that IV exists in methanol in a helical form. The synthesis of poly‐ L ‐lysyl rabbit serum albumin is also described.