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Copolymers of L ‐proline and sarcosine: Synthesis and physical‐chemical studies
Author(s) -
Fasman G. D.,
Blout E. R.
Publication year - 1963
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360010202
Subject(s) - sarcosine , copolymer , polyproline helix , chemistry , proline , optical rotatory dispersion , polymer chemistry , residue (chemistry) , stereochemistry , organic chemistry , polymer , circular dichroism , amino acid , glycine , biochemistry , peptide
A series of high molecular weight copolypeptides of L ‐proline and sarcosine have been synthesized. Experimental evidence is presented which indicates that the products are true copolymers rather than mixtures of homopolymers. In contrast to poly‐ L ‐proline I, a copolymer of L ‐proline‐sarcosine I containing approximately 50% sarcosine is soluble in water. Two molecular conformations of the copolymers, similar to those found for polyproline, have been characterized by means of infrared spectroscopy and optical rotatory dispersion. The residue rotation of L ‐proline has been obtained from the copolymers and is −250°.