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High molecular weight poly‐ L ‐proline: Synthesis and physical‐chemical studies
Author(s) -
Fasman G. D.,
Blout E. R.
Publication year - 1963
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.360010103
Subject(s) - polymerization , chemistry , polymer , polymer chemistry , proline , ultraviolet , organic chemistry , amino acid , materials science , biochemistry , optoelectronics
Poly‐ L ‐proline in the molecular weight range 50,000–90,000 has been synthesized from L ‐proline‐ N ‐carboxyanhydride. The molecular weight obtained is dependent on the initiator concentration. The rate constants for the polymerization have been determined by measuring the CO 2 evolution. By observation of rotation during the polymerization, it is possible to deduce the conformation of the polymer in the polymerization solution. It is concluded that the immediate product of the polymerization is neither pure form I nor pure form II. The differences between form I and form II of poly‐ L ‐proline have been further characterized by measurements of their ultraviolet rotatory dispersion and their ultraviolet spectra.