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Mechanisms of epitranscriptomic gene regulation
Author(s) -
Seo Kyung W.,
Kleiner Ralph E.
Publication year - 2021
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23403
Subject(s) - rna , biology , nucleic acid structure , gene expression , messenger rna , regulation of gene expression , computational biology , gene , microbiology and biotechnology , chemistry , genetics
Abstract Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional (“epitranscriptomic”) modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA‐protein interactions, RNA structure, and RNA‐RNA base pairing, and how these macromolecular interactions control biological processes in the cell.