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Publication year - 2021
Publication title -
biopolymers
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23374
Subject(s) - indel , cover (algebra) , mutation , genetics , gene duplication , computer science , order (exchange) , computational biology , citation , gene , information retrieval , artificial intelligence , world wide web , biology , single nucleotide polymorphism , genotype , engineering , business , mechanical engineering , finance
Gene mutation detection and identification are conducive for detection of disease. He, Sunil and team report the electronic characteristics of the gene of breast cancer 1 in four common mutation types: duplication, single nucleotide variation, deletion and indel. The HOMO (left) and HOMO‐1 (right) distribution for TCACAAGCA (above) and TCACXAGCA (below) explain the largest decrease in conductance upon deletion of an AT base pair. Each mutation shows a distinct change in conductance which can be used to identify the mutation. The results open up a new possibility for designing an efficient and low‐cost sensor for electronically detecting DNA mutations. (DOI: 10.1002/bip.23465 )