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Engineering repeat proteins of the immune system
Author(s) -
McCord Jennifer P.,
Grove Tijana Z.
Publication year - 2020
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23348
Subject(s) - glycan , glycoprotein , chemistry , biomolecule , computational biology , immune system , monomer , peptide , plasma protein binding , dna binding protein , antibody , protein engineering , biochemistry , microbiology and biotechnology , biology , genetics , gene , enzyme , organic chemistry , transcription factor , polymer
Abstract Limitations associated with immunoglobulins have motivated the search for novel binding scaffolds. Repeat proteins have emerged as one promising class of scaffolds, but often are limited to binding protein and peptide targets. An exception is the repeat proteins of the immune system, which have in recent years served as an inspiration for binding scaffolds which can bind glycans and other classes of biomolecule. Like other repeat proteins, these proteins can be very stable and have a monomeric mode of binding, with elongated and highly variable binding surfaces. The ability to target glycans and glycoproteins fill an important gap in current tools for research and biomedical applications.