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Bioactive glass functionalized chondroitin sulfate hydrogel with proangiogenic properties
Author(s) -
Zhang FengMiao,
Zhou Lei,
Zhou ZhengNan,
Dai Cong,
Fan Lei,
Li ChangHao,
Xiao CaiRong,
Ning ChengYun,
Liu Yi,
Du JianQiang,
Tan GuoXin
Publication year - 2019
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23328
Subject(s) - chemistry , covalent bond , chondroitin sulfate , composite number , self healing hydrogels , chemical engineering , methacrylate , bioactive glass , dynamic mechanical analysis , angiogenesis , polymer , polymer chemistry , polymerization , composite material , organic chemistry , materials science , biochemistry , glycosaminoglycan , engineering , medicine
Blood vessels play an important role in bone defect repair and growth, and a critical challenge of bone defect repair is the promotion of blood vessel formation. Most of the current methods promote vascularization by adding specific growth factors, which are costly and easy to inactivate. In this study, we developed a covalently cross‐linked aminated bioactive glass nanoparticle‐chondroitin sulfate methacrylate (ABGN‐CSMA) organic‐inorganic composite hydrogel with angiogenic properties. The amino groups of the ABGNs form covalent bonds with the carboxyl groups on CSMA. Surface amination modification of BGNs not only improved the dispersion of BGNs in CSMA but also significantly improved the mechanical properties of the composite hydrogel. The largest storage modulus (1200 Pa), the largest loss modulus (560 Pa) and the strongest resistance to deformation of the hydrogel are seen at 10% concentration of ABGNs. Simultaneously, the local pH stability and sustained ion release of the composite hydrogel are conducive to cell adhesion, proliferation, and angiogenesis. This work provides evidence for the development of covalently cross‐linked organic‐inorganic composite hydrogels with angiogenic properties.